In principle, this is an implementation of the basic ideas already presented nine years before, that residues show an asymmetric distribution within the heptad repeats and that this statistical data can be used to predict coiled coils in other proteins ( Parry, 1982). Subsequently, a similarity score is computed and a probability to form a coiled-coil calculated.
In this method a query sequence is compared with a database of known coiled-coil sequences, which were the KMTs available at that time. The basis for a coiled coil is an amino acid heptad (‘abcdefg’), in which the ‘a’ and ‘d’ positions are occupied by hydrophobic residues.Ĭoiled coils were among the first structural domains to be predicted by algorithms ( Lupas et al., 1991).
In the last years, this view has shifted to defining coiled-coil segments based on the presence of knobs-into-holes packing of side chains between α-helices resulting in many different architectures and topologies ( Moutevelis and Woolfson, 2009). The classical coiled coils comprise dimerising long α-helices that wind around each other forming superhelices ( Crick, 1952) as found in structural proteins such as α-keratins, muscle myosins and tropomyosin (KMTs). It seems this requires flatpak versions.Coiled coils are α-helical structural domains common to all domains of life and present in 2–12% of the proteins of a proteome ( Liu and Rost, 2001).
compatibility with the popular plugins (GMIC, resynthesize.) isn't clear.you may want to use Edit>Preferences>Folders to setup folders in more "visible" directories for your brushes, patterns, scripts and plugins.the Gimp profile is buried in ~/.var/app//config/GIMP/2.10/.the /tmp directory as seen by Gimp is remapped to a directory specific to flatpak, so you cannot share files through that (which is unfortunately required for some apps, such as web browsers).the "recent files" are not shared with other apps in the system.If you are used to "native" Gimp, be aware of some restrictions: The real installation is in /var/lib/flatpak/app// MimeType=image/bmp image/g3fax image/gif image/x-fits image/x-pcx image/x-portable-anymap image/x-portable-bitmap image/x-portable-graymap image/x-portable-pixmap image/x-psd image/x-sgi image/x-tga image/x-xbitmap image/x-xwindowdump image/x-xcf image/x-compressed-xcf image/x-gimp-gbr image/x-gimp-pat image/x-gimp-gih image/tiff image/jpeg image/x-psp application/postscript image/png image/x-icon image/x-xpixmap image/x-exr image/x-webp image/heif image/heic image/svg+xml application/pdf image/x-wmf image/jp2 image/x-xcursor Keywords=GIMP graphic design illustration painting To run Gimp: flatpak run AFAIK there is a desktop file somewhere, I have a ~/.local/share/applications/ with: Ĭategories=Graphics 2DGraphics RasterGraphics GTK Ĭomment=Create images and edit photographsĮxec=/usr/bin/flatpak run -branch=stable -arch=x86_64 -command=gimp-2.10 -file-forwarding %U Editor
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